The London Institute for Healthcare Engineering (LIHE), part of the vision for St Thomas’ MedTech Hub, is a joint initiative led by King’s School of Biomedical Engineering & Imaging Sciences and Guy’s and St Thomas’ NHS Foundation Trust. It will involve the construction of a new building embedded within St Thomas’ campus which will bring together King’s research excellence, Guy’s and St Thomas’ NHS Foundation Trust’s leading clinical practice and the medtech sector’s commercial innovation power and talent, engaging multinationals, SMEs and start-ups simultaneously. This close collaboration will ensure that research in healthcare engineering is translated rapidly into new products and technologies that will benefit patients sooner and more effectively. Design Approach The design meets the challenges of creating a place where innovation and collaboration is nurtured and facilitated by the built environment. A place where education and healthcare meet and innovation and research flourish. This new building will be located within the London Borough of Lambeth’s Albert Embankment Conservation Area, opposite the World Heritage Site of the Palace of Westminster and adjacent to the Grade I listed Lambeth Palace. The new building will sit amongst Henry Currey’s 1868 Grade II listed group of Venetian-inspired buildings, the first example of the pavilion type of hospital that was to become the standard for Victorian healthcare buildings. LIHE’s initial focus will be on key clinical challenges in cancer, neurological, cardiovascular, ophthalmology, oral health and prenatal conditions, which have been selected for their high disease burden and potential for transformation through healthcare engineering. Location of the new facility on the Guy’s and St Thomas’ hospital site enables researchers to easily access adjacent equipment and technology that allows them to quickly test prototypes. It is this gestation and testing of research ideas that really inspired how the building was designed, to be flexible and adaptable and to encourage encounters that lead to innovation.